Scientific Studies on Sputnik V and Sputnik Light Vaccines
Sputnik V demonstrates strong protection against Omicron variant, more than 2 times higher virus neutralizing activity than Pfizer vaccine against Omicron
- Sputnik V shows significantly smaller (2.6 times) reduction of virus neutralizing activity against Omicron (as compared to reference Wuhan variant) than for Pfizer (8.1-fold reduction for Sputnik V in contrast to 21.4-fold reduction for Pfizer vaccine)
- A unique comparative study conducted at the Italian Spallanzani Institute, the leading Italian research institute for infectious diseases, by the Institute and the Gamaleya Center, in the equal laboratory conditions on comparable sera samples
Neutralization antibody titer against Omicron
Source: «Retention of Neutralizing response against SARS-CoV-2 Omicron variant in Sputnik V vaccinated individuals»
The study demonstrates that Sputnik V neutralizes Omicron variant inducing robust antibody response associated with high levels of protection
- Among the top quartile of individuals with high RBD-specific IgG antibodies, 100% of those individuals vaccinated with Sputnik V were able to neutralize Omicron variant in comparison to 83.3% of individuals vaccinated with Pfizer
- Among all samples 74.2% of Sputnik V vaccinated sera were able to neutralize Omicron vs 56.9% for Pfizer vaccinated
% of sera with detectable NtAb*
Quartile
Sputnik V
Pfizer
Total
74.2
56.9
0-25%
25
15.4
>25-50%
87.5
46.2
>50-75%
87.5
76.9
>75-100%
100
83.3
0-50%
56.3
34.6
>50-100%
93.3
80.0
>25-75%
87.5
65.4
Each group of sera samples was divided into 7 parts according to RBD-specific IgG (BAU/ml) quartiles (0-25%, 25-50%, 50-75%, 75-100%, 0-50%, 25-75% and 50-100%)
*NtAb – neutralization antibody level